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Granular Cell Astrocytomas Show a High Frequency of Allelic Loss but are not a Genetically Defined Subset

1 Apr 2003

Abstract excerpt

Granular cell astrocytomas (GCA) are an uncommon morphologic variant of infiltrative glioma that contains a prominent population of atypical granular cells. As a rule, they are biologically aggressive compared to similar tumors without granular features. We sought to determine whether GCAs possess distinct genotypic alterations that might reflect their unique morphology or clinical behavior. Eleven GCAs occurring...

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PMID: 12744472
DOI: 10.1111/j.1750-3639.2003.tb00018.x

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