Article
Genome-wide array analysis of normal and malformed human hearts.
Circulation - 20 May 2003
Kaynak Bogac, von Heydebreck Anja, Mebus Siegrun, Seelow Dominik, Hennig Steffen, Vogel Jan, Sperling Hans-Peter, Pregla Reinhard, Alexi-Meskishvili Vladimir, Hetzer Roland, Lange Peter E, Vingron Martin, Lehrach Hans, Sperling Silke
Abstract excerpt
BACKGROUND: We present the first genome-wide cDNA array analysis of human congenitally malformed hearts and attempted to partially elucidate these complex phenotypes. Most congenital heart defects, which account for the largest number of birth defects in humans, represent complex genetic disorders. As a consequence of the malformation, abnormal hemodynamic features occur and cause an adaptation process of the...
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