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Article

Loss of mitotic spindle checkpoint activity predisposes to chromosomal instability at early stages of fibrosarcoma development.

Cell cycle (Georgetown, Tex.) - 1 Jan 2000

Gascoyne Duncan M, Hixon Mary L, Gualberto Antonio, Vivanco Maria D M

Abstract excerpt

Mice carrying the bovine papillomavirus type I genome develop dermal fibrosarcomas in a multiple step process characterized by distinctive proliferative stages. Chromosomal aberrations are identified early in this tumorigenic pathway, however, the mechanism that originates them is unknown. Using a functional assay, we investigated the status of the mitotic spindle cell cycle checkpoint (MSCCC) that regulates the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 12734433

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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