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Article

Preclinical evaluation of DISC-GMCSF for the treatment of breast carcinoma.

The journal of gene medicine - 1 May 2003

Loudon Peter T, McLean Cornelia S, Martin Gilly, Curry Jayne, Leigh Shaw M, Hoogstraten Conny, Verdegaal Els, Osanto Susanne

Abstract excerpt

BACKGROUND: DISC-hGMCSF is a gH-deleted HSV-2 based vector expressing human GM-CSF that has entered clinical trials for the therapy of metastatic melanoma. To determine whether this product also has potential to treat breast carcinoma, a series of in vitro and in vivo studies were made. METHODS: Breast carcinoma cell lines and primary cultures of breast carcinoma cells were infected with DISC-GFP or...

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PMID: 12731089
DOI: 10.1002/jgm.354

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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