Article
Polymorphism of the heat-shock protein gene Hsp70-2, but not polymorphisms of the IL-10 and CD14 genes, is associated with the outcome of Crohn's disease.
Scandinavian journal of gastroenterology - 1 Oct 2005
Klausz Gergely, Molnár Tamás, Nagy Ferenc, Gyulai Zsófia, Boda Krisztina, Lonovics János, Mándi Yvette
Abstract excerpt
OBJECTIVE: In Crohn's disease (CD) a Th-1 dominant immune reaction is induced, which could be associated with genetic predisposition. Several previous studies have investigated the roles of CD14, heat-shock protein (Hsp)70 and IL-10 gene polymorphisms in the development of the disease. The results are contradictory and inter-racial differences are implicated. Therefore, this phenomenon was evaluated in...
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