Article
Identification of a cross-reactive epitope widely present in lipopolysaccharide from enterobacteria and recognized by the cross-protective monoclonal antibody WN1 222-5.
The Journal of biological chemistry - 11 Jul 2003
Muller-Loennies Sven, Brade Lore, MacKenzie C Roger, Di Padova Franco E, Brade Helmut
Abstract excerpt
Septic shock due to infections with Gram-negative bacteria is a severe disease with a high mortality rate. We report the identification of the antigenic determinants of an epitope that is present in enterobacterial lipopolysaccharide (LPS) and recognized by a cross-reactive monoclonal antibody (m...
Topics
- Antibodies, Monoclonal
- Calorimetry
- Carbohydrate Sequence
- Dose-Response Relationship, Immunologic
- Enterobacteriaceae
- Enzyme-Linked Immunosorbent Assay
- Epitopes
- Escherichia coli
- Heptoses
- Kinetics
- Lipopolysaccharides