Article
No association between single nucleotide polymorphisms in DLX6 and Piccolo genes at 7q21-q22 and autism.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 15 May 2003
Nabi Rafiqun, Zhong Hailang, Serajee Fatema J, Huq A H M Mahbubul
Abstract excerpt
Several independent genome scans have revealed excess allele sharing in an overlapping 40 cM region of 7q21-34 in autism. DLX6 and Piccolo (PCLO) at 7q21-q22 are two positional and functional candidate genes in autism. We have investigated a single nucleotide polymorphism (SNP) in exon 4 of the PCLO gene and a SNP in intron 1 of the DLX6 gene for linkage and association in autistic disorder using both qualitative...
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