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Article

A genetic model for a central (septum transversum) congenital diaphragmatic hernia in mice lacking Slit3

17 Apr 2003

Abstract excerpt

Congenital diaphragmatic hernia (CDH) is a significant cause of pediatric mortality in humans with a heterogeneous and poorly understood etiology. Here we show that mice lacking Slit3 developed a central (septum transversum) CDH. Slit3 encodes a member of the Slit family of guidance molecules and is expressed predominantly in the mesothelium of the diaphragm during embryonic development. In Slit3 null mice, the...

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PMID: 12702769
DOI: 10.1073/pnas.0730709100

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