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Article

Engineering of the metabolism of Saccharomyces cerevisiae for anaerobic production of mannitol.

FEMS yeast research - 1 Mar 2003

Costenoble Roeland, Adler Lennart, Niklasson Claes, Lidén Gunnar

Abstract excerpt

Under anaerobic conditions, Saccharomyces cerevisiae uses NADH-dependent glycerol-3-phosphate dehydrogenase (Gpd1p and Gpd2p) to re-oxidize excess NADH, yielding substantial amounts of glycerol. In a Deltagpd1 Deltagpd2 double-null mutant, the necessary NAD+ regeneration through glycerol production is no longer possible, and this mutant does not grow under anaerobic conditions. The excess NADH formed can...

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PMID: 12702242
DOI: 10.1111/j.1567-1364.2003.tb00134.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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