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Article

Efficacy of adenoviral p53 delivery with SCH58500 in the intracranial 9l and RG2 models.

Frontiers in bioscience : a journal and virtual library - 1 May 2003

Bowers Geoffrey, He Ju, Schulz Karl, Olivarria Gregory, Maneval Dan, Olson Jeffrey J

Abstract excerpt

Malignant gliomas remain incurable entities that provide fertile ground for experimental therapy. The observation that impaired p53 expression is present in a proportion of these tumors suggests that reconstitution of this ability may impart some degree of tumor control. In this investigation, the 9L and RG2 intracranial rodent tumor models are utilized to assess SCH58500, an adenoviral p53 delivery system. The...

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PMID: 12700117
DOI: 10.2741/946

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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