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Article

The Hsp70 and TRiC/CCT chaperone systems cooperate in vivo to assemble the von Hippel-Lindau tumor suppressor complex.

Molecular and cellular biology - 1 May 2003

Melville Mark W, McClellan Amie J, Meyer Anne S, Darveau Andre, Frydman Judith

Abstract excerpt

The degree of cooperation and redundancy between different chaperones is an important problem in understanding how proteins fold in the cell. Here we use the yeast Saccharomyces cerevisiae as a model system to examine in vivo the chaperone requirements for assembly of the von Hippel-Lindau protein (VHL)-elongin BC (VBC) tumor suppressor complex. VHL and elongin BC expressed in yeast assembled into a correctly...

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Identifiers

PMID: 12697815
DOI: 10.1128/MCB.23.9.3141-3151.2003
PMCID: PMC153194

Genes

VHL
CCT4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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