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Article

Identification of a quinoxaline derivative that is a potent telomerase inhibitor leading to cellular senescence of human cancer cells.

The Biochemical journal - 15 Jul 2003

Kim Jun Hyun, Kim Joo Hee, Lee Gun Eui, Kim Sang Woong, Chung In Kwon

Abstract excerpt

Telomere maintenance is essential for the continued proliferation of dividing cells, and is implicated in chromosome stability and cell immortalization. Telomerase activity allows cells to maintain their telomeric DNA and contributes to the indefinite replicative capacity of cancer cells. Telomer...

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Identifiers

PMID: 12689331
DOI: 10.1042/BJ20030363
PMCID: PMC1223492

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12689331-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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