Article
Mapping of functional domains and characterization of the transcription factor Cph1 that mediate morphogenesis in Candida albicans.
Fungal genetics and biology : FG & B - 1 Oct 2015
Maiti Protiti, Ghorai Priyanka, Ghosh Sumit, Kamthan Mohan, Tyagi Rakesh Kumar, Datta Asis
Abstract excerpt
Cph1, a transcription factor of the Mitogen Activated Protein (MAP) kinase pathway, regulates morphogenesis in human fungal pathogen Candida albicans. Here, by following a systemic deletion approach, we have identified functional domains and motifs of Cph1 that are involved in transcription factor activity and cellular morphogenesis. We found that the N-terminal homeodomain is essential for the DNA binding...
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