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Article

[Molecular aspects of pharmacological activity of naltrexone and naloxone].

Eksperimental'naia i klinicheskaia farmakologiia - 1 Jan 2000

Golovko A I, Golovko S I, Leont'eva L V, Romanenko O I, Konoplin D A

Abstract excerpt

Naltrexone and naloxone, being competitive antagonists of opioid receptors, have found therapeutic applications in medicine. The experiments with mutant receptors showed that many amino acid residues within transmembrane domains play an important role in binding these drugs. Using the site-direct...

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PMID: 12683088

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12683088-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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