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Article

Postnatal NG2 proteoglycan-expressing progenitor cells are intrinsically multipotent and generate functional neurons.

The Journal of cell biology - 14 Apr 2003

Belachew Shibeshih, Chittajallu Ramesh, Aguirre Adan A, Yuan Xiaoqing, Kirby Martha, Anderson Stacie, Gallo Vittorio

Abstract excerpt

Neurogenesis is known to persist in the adult mammalian central nervous system (CNS). The identity of the cells that generate new neurons in the postnatal CNS has become a crucial but elusive issue. Using a transgenic mouse, we show that NG2 proteoglycan-positive progenitor cells that express the 2',3'-cyclic nucleotide 3'-phosphodiesterase gene display a multipotent phenotype in vitro and generate electrically...

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Identifiers

PMID: 12682089
DOI: 10.1083/jcb.200210110
PMCID: PMC2172886

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Source receipt: pubmed, retrieved 7 Sept 2026.

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