Of mice and men: Reconciling preclinical ALS mouse studies and human clinical trials

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is largely a sporadic adult-onset neurodegenerative disease. For many decades, attempts at therapies for this disease were typically small, inadequately powered clinical trials often based on anecdotal observations, with intentions of reversing the disease. In this issue of Annals, two separate studies provide an opportunity to reflect on how we decide to investigate drugs for...

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