Article
Identification of CGI-121, a novel PRPK (p53-related protein kinase)-binding protein.
Biochemical and biophysical research communications - 4 Apr 2003
Miyoshi Akifumi, Kito Katsumi, Aramoto Takayoshi, Abe Yasuhito, Kobayashi Nobuaki, Ueda Norifumi
Abstract excerpt
PRPK (p53-related protein kinase) has been reported as a novel protein kinase which binds to the tumor suppressor protein p53 and induces phosphorylation of p53 at Ser 15. To identify novel binding partners of PRPK, we performed a yeast two-hybrid screening and isolated an expressed sequence tag CGI-121 by which a 20-kDa protein was encoded. We demonstrated the protein-protein interaction of CGI-121 with PRPK in...
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