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Article

Integrins and extracellular matrix: a novel mechanism of multidrug resistance

1 Aug 2002

Abstract excerpt

Multidrug resistance remains the major hurdle to successful cancer treatment. Classical mechanisms of multidrug resistance include drug efflux pumps, glutathione-S-transferase upregulation and topoisomerase II-associated multidrug resistance. However, despite extensive research, the clinical relevance of these mechanisms remains unclear and no significant clinical benefit has materialized. Recently, a novel...

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PMID: 12647988
DOI: 10.1586/14737140.2.4.449

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