Article
Arginine 25 and Arginine 28 of lactoferrin are critical for effective heparin neutralization in blood.
Archives of biochemistry and biophysics - 1 Apr 2003
Wu Haifeng M, Church Frank C
Abstract excerpt
The interaction of lactoferrin with endogenous heparin-like molecules modulates glycosaminoglycan-mediated biological processes. We performed site-specific mutagenesis and expressed recombinant lactoferrin and lactoferrin mutants by the baculovirus insect cell expression system. Five basic residues at the lactoferrin N terminus; Arg 5, Arg 25, Arg 28, Lys 29, and Arg 31, were individually replaced by alanines....
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