Article
The role of T lymphocytes in the pathogenesis of asthma.
The Journal of allergy and clinical immunology - 1 Mar 2003
Larché Mark, Robinson Douglas S, Kay A Barry
Abstract excerpt
There is considerable evidence to support a role for T cells in asthma, particularly the involvement of T(H)2 cells both in atopic allergic asthma and in nonatopic and occupational asthma. There might also be a minor contribution from T(C)2 CD8+ T cells. Several T(H)2 cytokines have the potential to modulate airway inflammation, particularly IL-13, which induces airway hyperresponsiveness independently of IgE and...
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