Article
Allelic variants of the functional promoter polymorphism of the human serotonin transporter gene is associated with auditory cortical stimulus processing.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Mar 2003
Gallinat Jürgen, Senkowski Daniel, Wernicke Catrin, Juckel Georg, Becker Isabell, Sander Thomas, Smolka Michael, Hegerl Ulrich, Rommelspacher Hans, Winterer Georg, Herrmann Werner M
Abstract excerpt
The loudness dependence (LD) of the auditory-evoked N1/P2 component has been shown to be related to the central serotonergic neurotransmission. Allelic variants in the promoter region of the 5-hydroxytryptamine transporter (5-HTT) gene were shown to modulate serotonergic activity. It was hypothesized that the three genotypes (l/l, s/l, s/s) differ with respect to LD. Allelic variants of the 5-HTT promoter region...
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