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Article

Decreased Efficiency of Adenovirus-Mediated Gene Transfer in Aging Cardiomyocytes

3 Mar 2003

Abstract excerpt

BACKGROUND: Aging is an independent risk factor for the development of cardiovascular disease. Clinical application of myocardial gene transfer may be best suited in the elderly. In vivo gene transfer by adenovirus is less efficient in aging myocardium. METHODS AND RESULTS: When infected with adenovirus containing beta-galactosidase (beta-gal) and green fluorescent protein (GFP) driven by cytomegalovirus...

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PMID: 12615797
DOI: 10.1161/01.cir.0000051467.31874.29

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