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Article

PopHist: inferring population history from the spectrum of allele frequencies.

Bioinformatics (Oxford, England) - 1 Mar 2003

Wooding Stephen

Abstract excerpt

SUMMARY: PopHist is a computer program that uses the frequency spectrum of alleles to: (a) estimate maximum likelihood parameters describing a population's history; and (b) compare alternative hypotheses about population history using likelihood ratio tests. The program uses the matrix coalescent, a method for calculating theoretical frequency spectra that can be applied to sets of unlinked sites. AVAILABILITY:...

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PMID: 12611810
DOI: 10.1093/bioinformatics/btg024

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