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Article

PopHist: inferring population history from the spectrum of allele frequencies.

Bioinformatics (Oxford, England) - 1 Mar 2003

Wooding Stephen

Abstract excerpt

SUMMARY: PopHist is a computer program that uses the frequency spectrum of alleles to: (a) estimate maximum likelihood parameters describing a population's history; and (b) compare alternative hypotheses about population history using likelihood ratio tests. The program uses the matrix coalescent, a method for calculating theoretical frequency spectra that can be applied to sets of unlinked sites. AVAILABILITY:...

Topics

Algorithms
Alleles
Animals
Biological Evolution
Computer Simulation
DNA Mutational Analysis
Gene Frequency
Humans
Likelihood Functions
Models, Genetic
Models, Statistical
Polymorphism, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Population

Population Dynamics

Sequence Analysis, DNA

Software

Source

Identifiers

PMID: 12611810
DOI: 10.1093/bioinformatics/btg024

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