The phenotype of Hurthle and Warthin-like papillary thyroid carcinomas is distinct from classic papillary carcinoma as to the expression of retinoblastoma protein and E2F-1 transcription factor.

Abstract excerpt

Retinoblastoma protein plays an important role in controlling cell cycle progression. The active form of retinoblastoma protein binds to E2F-1 and inhibits transcription of S phase genes. Overexpression of E2F-1 has been suggested as an important factor in carcinogenesis. The Hurthle cell (HPCA)...

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