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Article

Higher farnesyl diphosphate synthase activity in human colorectal cancer inhibition of cellular apoptosis.

Oncology - 1 Jan 2004

Notarnicola Maria, Messa Caterina, Cavallini Aldo, Bifulco Maurizio, Tecce Mario Felice, Eletto Davide, Di Leo Alfredo, Montemurro Severino, Laezza Chiara, Caruso Maria Gabriella

Abstract excerpt

OBJECTIVE: Farnesyl diphosphate synthase (FPPs) produces FPP which is considered a branch-point intermediate in the synthesis of sterols and isoprenylated cellular metabolites. In this study we investigated whether detectable FPPs activity was present in human colorectal cancer (CRC), also evaluating in vitro the role of this enzyme in the growth and apoptosis of CRC cells by using Pamidronate (PAM), a FPPs...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15713990
DOI: 10.1159/000082918

Genes

PAM
DLD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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