Article
Requirement for the synaptic protein interaction site for reconstitution of synaptic transmission by P/Q-type calcium channels.
Proceedings of the National Academy of Sciences of the United States of America - 4 Mar 2003
Mochida Sumiko, Westenbroek Ruth E, Yokoyama Charles T, Zhong Huijun, Myers Scott J, Scheuer Todd, Itoh Kanako, Catterall William A
Abstract excerpt
Ca(v)2.1 channels, which conduct P/Q-type Ca(2+) currents, were expressed in superior cervical ganglion neurons in cell culture, and neurotransmission initiated by these exogenously expressed Ca(2+) channels was measured. Deletions in the synaptic protein interaction (synprint) site in the intracellular loop between domains II and III of Ca(v)2.1 channels reduced their effectiveness in synaptic transmission....
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