Article
Hematopoiesis-restricted minor histocompatibility antigens HA-1- or HA-2-specific T cells can induce complete remissions of relapsed leukemia.
Proceedings of the National Academy of Sciences of the United States of America - 4 Mar 2003
Marijt W A Erik, Heemskerk Mirjam H M, Kloosterboer Freke M, Goulmy Els, Kester Michel G D, van der Hoorn Menno A W G, van Luxemburg-Heys Simone A P, Hoogeboom Manja, Mutis Tuna, Drijfhout Jan Wouter, van Rood Jon J, Willemze Roel, Falkenburg J H Frederik
Abstract excerpt
Donor lymphocyte infusion (DLI) into patients with a relapse of their leukemia or multiple myeloma after allogeneic stem cell transplantation (alloSCT) has been shown to be a successful treatment approach. The hematopoiesis-restricted minor histocompatibility antigens (mHAgs) HA-1 or HA-2 expressed on malignant cells of the recipient may serve as target antigens for alloreactive donor T cells. Recently we treated...
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