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Article

Advantages of using mitochondrial 16S rDNA sequences to classify clinical isolates of Acanthamoeba.

Investigative ophthalmology & visual science - 1 Mar 2003

Ledee Dolena R, Booton Gregory C, Awwad Mohammed H, Sharma Savitri, Aggarwal Ramesh K, Niszl Ingrid A, Markus Miles B, Fuerst Paul A, Byers Thomas J

Abstract excerpt

PURPOSE: This work was intended to test the classification of Acanthamoeba into genotypes based on nuclear ribosomal RNA gene (18S rDNA, Rns) sequences. Nearly all Acanthamoeba keratitis (AK) isolates are genotype RnsT4. This marked phylogenetic localization is presumably either due to an innate potential for pathogenicity or to a peculiarity of the gene sequences used. To differentiate between these...

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PMID: 12601042
DOI: 10.1167/iovs.02-0485

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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