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Article

Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide.

Science (New York, N.Y.) - 21 Feb 2003

Kim Un-kyung, Jorgenson Eric, Coon Hilary, Leppert Mark, Risch Neil, Drayna Dennis

Abstract excerpt

The ability to taste the substance phenylthiocarbamide (PTC) has been widely used for genetic and anthropological studies, but genetic studies have produced conflicting results and demonstrated complex inheritance for this trait. We have identified a small region on chromosome 7q that shows strong linkage disequilibrium between single-nucleotide polymorphism (SNP) markers and PTC taste sensitivity in unrelated...

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Identifiers

PMID: 12595690
DOI: 10.1126/science.1080190

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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