Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide.

doi:10.1126/science.1080190

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Article

Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide.

Science (New York, N.Y.) - 21 Feb 2003

Kim Un-kyung, Jorgenson Eric, Coon Hilary, Leppert Mark, Risch Neil, Drayna Dennis

Abstract excerpt

The ability to taste the substance phenylthiocarbamide (PTC) has been widely used for genetic and anthropological studies, but genetic studies have produced conflicting results and demonstrated complex inheritance for this trait. We have identified a small region on chromosome 7q that shows stron...

Topics

Alleles
Amino Acid Substitution
Animals
Cebidae
Chromosomes, Human, Pair 7
Cloning, Molecular
Computational Biology
Evolution, Molecular
Female
Genetic Linkage
Haplotypes
Heterozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hominidae

Homozygote

Humans

Linkage Disequilibrium

Macaca fascicularis

Male

Source

Open in PubMed

Identifiers

PMID: 12595690
DOI: 10.1126/science.1080190

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-12595690-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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