Article
Isolation and genetic analysis of a mutation that suppresses the auxotrophies of superoxide dismutase-deficient Escherichia coli K12.
Molecular & general genetics : MGG - 1 Sept 1991
Imlay J A, Fridovich I
Abstract excerpt
The most striking phenotype associated with superoxide dismutase (SOD) deficiency in Escherichia coli is the inability to grow in aerobic minimal medium, which is due to the sensitivity of several amino acid biosynthetic pathways to superoxide. We have isolated two classes of pseudorevertants that grow on minimal medium at modest rates. Of these, the class that exhibited the faster growth carries mutations at a...
Topics
- Alleles
- Chromosome Mapping
- Chromosomes, Bacterial
- Escherichia coli
- Genes, Bacterial
- Mutation
- Phenotype
- Restriction Mapping
- Superoxide Dismutase