Article
Diagnostic paradigm for evaluation of male patients with chronic granulomatous disease, based on the dihydrorhodamine 123 assay.
The Journal of allergy and clinical immunology - 1 Feb 2003
Jirapongsananuruk Orathai, Malech Harry L, Kuhns Douglas B, Niemela Julie E, Brown Margaret R, Anderson-Cohen Mindy, Fleisher Thomas A
Abstract excerpt
BACKGROUND: Chronic granulomatous disease (CGD) is a phagocyte disorder caused by mutations in nicotinamide dinucleotide phosphate (NADPH) oxidase subunits. The dihydrorhodamine 123 (DHR) assay is an effective test for CGD that for most patients also might help to differentiate between the 2 most common forms, X-linked (X) gp91(phox) defect CGD and autosomal recessive (AR) p47(phox) defect CGD. However, some male...
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