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Article

Focus on FOCIS: the continuing diagnostic challenge of autosomal recessive chronic granulomatous disease.

Clinical immunology (Orlando, Fla.) - 1 Aug 2008

Yu Grace, Hong David K, Dionis Kira Y, Rae Julie, Heyworth Paul G, Curnutte John T, Lewis David B

Abstract excerpt

Chronic granulomatous disease (CGD) is a primary immunodeficiency of defective neutrophil oxidative burst activity due to mutations in the genes CYBA, NCF-1, NCF-2, and CYBB, which respectively encode the p22-phox, p47-phox, p67-phox, and gp91-phox subunits. CGD usually presents in early childhood with recurrent or severe infection with catalase-positive bacteria and fungi. We present an unusual case of CGD in...

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Source

Identifiers

PMID: 18625437
DOI: 10.1016/j.clim.2008.05.008

Genes

CYBA
CYBB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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