Article
A quantitative trait locus on chromosome 16q influences variation in plasma HDL-C levels in Mexican Americans.
Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2003
Mahaney M C, Almasy L, Rainwater D L, VandeBerg J L, Cole S A, Hixson J E, Blangero J, MacCluer J W
Abstract excerpt
OBJECTIVE: We conducted a whole-genome, multipoint linkage screen to localize a previously reported major locus accounting for 56% to 67% of the additive genetic effects on covariate-adjusted plasma HDL cholesterol (HDL-C) levels in Mexican Americans from the San Antonio Family Heart Study (SAFHS). METHODS AND RESULTS: After using complex segregation analysis to recover the major locus in 472 SAFHS participants...
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