Article
Lack of prediction of mefloquine and mefloquine-artesunate treatment outcome by mutations in the Plasmodium falciparum multidrug resistance 1 (pfmdr1) gene for P. falciparum malaria in Peru.
The American journal of tropical medicine and hygiene - 1 Jan 2003
Pillai Dylan R, Hijar Gisely, Montoya Ysabel, Marouiño Wilmer, Ruebush Trenton K, Wongsrichanalai Chansuda, Kain Kevin C
Abstract excerpt
We assessed whether mutations in the Plasmodium falciparum multidrug-resistance gene 1 (pfmdr1) (C1034S, D1042N, and Y1246D) would predict treatment outcome during a 28-day in vivo treatment trial in the Peruvian Amazon. Mefloquine (MQ) was compared with mefloquine-artesunate (MQ-AS) in a randomized, multi-clinic protocol for the first time in the Americas. Of 115 patients enrolled in the in vivo arm, 97 patients...
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