Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of N-acetyltransferase-2 and glutathione S-transferase on the risk and aggressiveness of bladder cancer.

Anticancer research - 1 Jan 2000

Giannakopoulos Xenofon, Charalabopoulos Konstantin, Baltogiannis Dimitrios, Chatzikiriakidou Anthi, Alamanos Yannis, Georgiou Ioannis, Evangelou Angelos, Agnantis Niki, Sofikitis Nikolaos

Abstract excerpt

N-acetyltransferase-2 (NAT-2) and Glutathione-S-transferase M1 and T1 (GSTM1 and GSTT1) polymorphism have been implicated in the detoxification of urothelial carcinogens, such as arylamines and polycyclic aromatic hydrocarbons. The results of epidemiological studies examining the role of NAT-2, GSTM1 and GSTT1 genotypes on the risk factors for bladder cancer were controversial, although suggesting that there may...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arylamine N-Acetyltransferase
Share to Carcinoma, Transitional Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Case-Control Studies

Share to Glutathione Transferase

Share to Neoplasm Invasiveness

Share to Neoplasm Staging

Share to Risk Factors

Share to Urinary Bladder Neoplasms

Source

Identifiers

PMID: 12552997

Genes

GSTM1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of N-acetyltransferase-2 and glutathione S-transferase on the risk and aggressiveness of bladder cancer.PMID 12552997Read ↗

Gender-specific effects of NAT2 and GSTM1 in bladder cancer.Semantic proximity Read ↗

N-acetyltransferase 2 and bladder cancer: an overview and consideration of the evidence for gene-environment interaction.Semantic proximity Read ↗

Arylamine N-acetyltransferase 1 (NAT1) and 2 (NAT2) polymorphisms in susceptibility to bladder cancer: the influence of smoking.Semantic proximity Read ↗

Genotypes of N-acetyltransferase-2 and risk of bladder cancer: a case-control study.Semantic proximity Read ↗

Association of NAT2, GSTM1, GSTT1, CYP2A6, and CYP2A13 gene polymorphisms with susceptibility and clinicopathologic characteristics of bladder cancer in Central China.Semantic proximity Read ↗

Modifying Effect of Smoking on GSTM1 and NAT2 in Relation to the Risk of Bladder Cancer in Mongolian Population: A Case-Control Study.Semantic proximity Read ↗

NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses.Semantic proximity Read ↗

Combined effect of smoking and inherited polymorphisms in arylamine N-acetyltransferase 2, glutathione S-transferases M1 and T1 on bladder cancer in a Tunisian population.Semantic proximity Read ↗

N-acetyltransferase 2 polymorphism is associated with bladder cancer risk: An updated meta-analysis based on 54 case-control studies.Semantic proximity Read ↗

Do smoking and polymorphisms in xenobiotic metabolizing enzymes affect the histological stage and grade of bladder tumors?Semantic proximity Read ↗

Joint effects of the N-acetyltransferase 1 and 2 (NAT1 and NAT2) genes and smoking on bladder carcinogenesis: a literature-based systematic HuGE review and evidence synthesis.Semantic proximity Read ↗

Glutathione S-transferase (GST) M1, T1 and N-acetyltransferase 2 (NAT2) polymorphisms and urothelial cancer risk with tobacco smoking.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.