Article
Characterization of tissue tropism determinants of adeno-associated virus type 1.
Journal of virology - 1 Feb 2003
Hauck Bernd, Xiao Weidong
Abstract excerpt
Muscle is an attractive target for gene delivery because of its mass and because vectors can be delivered in a noninvasive fashion. Adeno-associated virus (AAV) has been shown to be effective for muscle-targeted gene transfer. Recent progress in characterization of AAV serotype 1 (AAV1) and AAV6 demonstrated that these two AAV serotypes are far more efficient in transducing muscle than is the traditionally used...
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