Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of a Receptor-Binding Domain of the Spike Glycoprotein of Human Coronavirus HCoV-229E

28 Jan 2003

Abstract excerpt

Human coronavirus HCoV-229E uses human aminopeptidase N (hAPN) as its receptor (C. L. Yeager et al., Nature 357:420-422, 1992). To identify the receptor-binding domain of the viral spike glycoprotein (S), we expressed soluble truncated histidine-tagged S glycoproteins by using baculovirus expression vectors. Truncated S proteins purified by nickel affinity chromatography were shown to be glycosylated and to react...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animal Virus Infections Studies
Share to SARS-CoV-2 and COVID-19 Research
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12551991
DOI: 10.1128/jvi.77.4.2530-2538.2003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

Identification of a Receptor-Binding Domain of the Spike Glycoprotein of Human Coronavirus HCoV-229EPMID 12551991Read ↗

Identification of the Receptor-Binding Domain of the Spike Glycoprotein of Human Betacoronavirus HKU1Semantic proximity Read ↗

Highly Conserved Regions within the Spike Proteins of Human Coronaviruses 229E and NL63 Determine Recognition of Their Respective Cellular ReceptorsSemantic proximity Read ↗

Membrane Protein of Human Coronavirus NL63 Is Responsible for Interaction with the Adhesion ReceptorSemantic proximity Read ↗

Human Coronavirus 229E Infects Polarized Airway Epithelia from the Apical SurfaceSemantic proximity Read ↗

Identification of Major Histocompatibility Complex Class I C Molecule as an Attachment Factor That Facilitates Coronavirus HKU1 Spike-Mediated InfectionSemantic proximity Read ↗

Amino acids 270 to 510 of the severe acute respiratory syndrome coronavirus spike protein are required for interaction with receptor.Semantic proximity Read ↗

Identification of residues critical for the human coronavirus 229E receptor function of human aminopeptidase N.Semantic proximity Read ↗

Communication between S1N330 and a region in S2 of murine coronavirus spike protein is important for virus entry into cells expressing CEACAM1b receptor.Semantic proximity Read ↗

Determinants essential for the transmissible gastroenteritis virus-receptor interaction reside within a domain of aminopeptidase-N that is distinct from the enzymatic siteSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.