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Identification of the Receptor-Binding Domain of the Spike Glycoprotein of Human Betacoronavirus HKU1

18 Jun 2015

Abstract excerpt

UNLABELLED: Coronavirus spike (S) glycoproteins mediate receptor binding, membrane fusion, and virus entry and determine host range. Murine betacoronavirus (β-CoV) in group A uses the N-terminal domain (NTD) of S protein to bind to its receptor, whereas the β-CoVs severe acute respiratory syndrome CoV in group B and Middle East respiratory syndrome CoV in group C and several α-CoVs use the downstream C domain in...

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PMID: 26085157
DOI: 10.1128/jvi.03737-14

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