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The effects of chemotherapy with bleomycin, etoposide, and cis‐platinum on telomeres in rat male germ cells

7 Oct 2015

Abstract excerpt

Co-administration of bleomycin, etoposide, and cis-platinum (BEP) has increased the 5-year survival rate of testis cancer patients to over 90%; however, this treatment induces chemotoxic effects on male germ cells. Treatment of male rats with BEP, using a similar schedule to that used in man, affects reproductive organ weights and sperm count, motility, and DNA integrity, as well as pup survival rates. Telomeres,...

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Share to Advanced biosensing and bioanalysis techniques
Share to Chromosomal and Genetic Variations
Share to Telomeres, Telomerase, and Senescence

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PMID: 26446377
DOI: 10.1111/andr.12102

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