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Article

Dihydropyrimidine dehydrogenase pharmacogenetics in Caucasian subjects.

British journal of clinical pharmacology - 1 Aug 1998

Ridge S A, Sludden J, Brown O, Robertson L, Wei X, Sapone A, Fernandez-Salguero P M, Gonzalez F J, Vreken P, van Kuilenburg A B, van Gennip A H, McLeod H L

Abstract excerpt

AIMS: Dihydropyrimidine dehydrogenase (DPD) catalyses the reduction of pyrimidines, including the anticancer agent 5-fluorouracil (5FU). Impaired 5FU degradation, through low DPD activity, has led to severe, life-threatening or fatal toxicity after administration of 5FU. Complete DPD deficiency i...

Topics

Alleles
Dihydrouracil Dehydrogenase (NADP)
Female
Humans
Leukocytes, Mononuclear
Male
Oxidoreductases
Point Mutation
Scotland
Smoking
White People

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Identifiers

PMID: 9723824
DOI: 10.1046/j.1365-2125.1998.00751.x
PMCID: PMC1873668

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9723824-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Dihydropyrimidine dehydrogenase pharmacogenetics in Caucasian subjects.PMID 9723824Read ↗

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High-throughput genotyping by DHPLC of the dihydropyrimidine dehydrogenase gene implicated in (fluoro)pyrimidine catabolism.Semantic proximity Read ↗

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Known variant DPYD alleles do not explain DPD deficiency in cancer patients.Semantic proximity Read ↗

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Dihydropyrimidine dehydrogenase deficiency, a pharmacogenetic syndrome associated with potentially life-threatening toxicity following 5-fluorouracil administration.Semantic proximity Read ↗

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Clinical Pharmacogenetics Implementation Consortium guidelines for dihydropyrimidine dehydrogenase genotype and fluoropyrimidine dosing.Semantic proximity Read ↗

Implications of Dihydropyrimidine Dehydrogenase on 5-Fluorouracil Pharmacogenetics and PharmacogenomicsSemantic proximity Read ↗

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