Article
Diversity of mouse proton-translocating ATPase: presence of multiple isoforms of the C, d and G subunits.
Gene - 2 Jan 2003
Sun-Wada Ge-Hong, Yoshimizu Takao, Imai-Senga Yoko, Wada Yoh, Futai Masamitsu
Abstract excerpt
Vacuolar-type proton-translocating ATPases (V-ATPases), multimeric proton pumps, are involved in a wide variety of physiological processes. For their diverse functions, V-ATPases utilize a specific subunit isoform(s). Here, we reported the molecular cloning and characterization of three novel subunit isoforms, C2, d2 and G3, of mouse V-ATPase. These isoforms were expressed in a tissue-specific manner, in contrast...
Topics
- Amino Acid Sequence
- Animals
- Blotting, Northern
- Cloning, Molecular
- DNA, Complementary
- Gene Expression Regulation, Enzymologic
- Genetic Complementation Test
- Genetic Variation
- Male
- Mice
- Molecular Sequence Data
- Mutation
- Protein Isoforms
- Protein Subunits