Article
Genome-wide survey of V-ATPase genes in Drosophila reveals a conserved renal phenotype for lethal alleles.
Physiological genomics - 14 Jul 2005
Allan Adrian K, Du Juan, Davies Shireen A, Dow Julian A T
Abstract excerpt
V-ATPases are ubiquitous, vital proton pumps that play a multiplicity of roles in higher organisms. In many epithelia, they are the major energizer of cotransport processes and have been implicated in functions as diverse as fluid secretion and longevity. The first animal knockout of a V-ATPase was identified in Drosophila, and its recessive lethality demonstrated the essential nature of V-ATPases. This article...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.