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Article

Accelerated protein evolution and origins of human-specific features: Foxp2 as an example.

Genetics - 1 Dec 2002

Zhang Jianzhi, Webb David M, Podlaha Ondrej

Abstract excerpt

Genes responsible for human-specific phenotypes may have been under altered selective pressures in human evolution and thus exhibit changes in substitution rate and pattern at the protein sequence level. Using comparative analysis of human, chimpanzee, and mouse protein sequences, we identified two genes (PRM2 and FOXP2) with significantly enhanced evolutionary rates in the hominid lineage. PRM2 is a histone-like...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12524352
DOI: 10.1093/genetics/162.4.1825
PMCID: PMC1462353

Genes

FOXP2
PRM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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