Altersetin, a New Antibiotic from Cultures of Endophytic Alternaria spp. Taxonomy, Fermentation, Isolation, Structure Elucidation and Biological Activities.

Abstract excerpt

A novel antibacterial antibiotic, for which the name altersetin is proposed, was isolated from the culture broth of two endophytic Alternaria species. The relative and absolute configuration were assigned by NOESY or CD data, respectively. Altersetin is chemically related to equisetin and showed potent MIC against several pathogenic gram-positive bacteria, whereas gram-negative bacteria and pathogenic yeast were...

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