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Total Synthesis and Biological Investigation of (−)-Promysalin

29 May 2015

Abstract excerpt

Compounds that specifically target pathogenic bacteria are greatly needed, and identifying the method by which they act would provide new avenues of treatment. Herein we report the concise, high-yielding total synthesis (eight steps, 35% yield) of promysalin, a natural product that displays antivirulence phenotypes against pathogenic bacteria. Guided by bioinformatics, four diastereomers were synthesized, and the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 26024439
DOI: 10.1021/jacs.5b04767

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