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Novel regulators of vitamin D action and metabolism: Lessons learned at the Los Angeles zoo

6 Jan 2003

Abstract excerpt

We undertook an investigation of an outbreak of rachitic bone disease in the Emperor Tamarin New World primate colony at the Los Angeles Zoo in the mid-1980s. The disease phenotype resembled that observed in humans with an inactivating mutation of the vitamin D receptor (VDR), hypocalcemia, high 1,25-dihydroxyvitamin D (1,25-(OH)(2)D) levels, and rickets in rapidly growing adolescent primates. In contrast to the...

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PMID: 12520531
DOI: 10.1002/jcb.10333

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