Article
Coordinate changes in Myosin heavy chain isoform gene expression are selectively associated with alterations in dilated cardiomyopathy phenotype.
Molecular medicine (Cambridge, Mass.) - 1 Nov 2002
Abraham W T, Gilbert E M, Lowes B D, Minobe W A, Larrabee P, Roden R L, Dutcher D, Sederberg J, Lindenfeld J A, Wolfel E E, Shakar S F, Ferguson D, Volkman K, Linseman J V, Quaife R A, Robertson A D, Bristow M R
Abstract excerpt
BACKGROUND: The most common cause of chronic heart failure in the US is secondary or primary dilated cardiomyopathy (DCM). The DCM phenotype exhibits changes in the expression of genes that regulate contractile function and pathologic hypertrophy. However, it is unclear if any of these alterations in gene expression are disease producing or modifying. MATERIALS AND METHODS: One approach to providing evidence for...
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