Article
NOVP chemotherapy for Hodgkin's disease transiently induces sperm aneuploidies associated with the major clinical aneuploidy syndromes involving chromosomes X, Y, 18, and 21.
Cancer research - 1 Jan 2003
Frias Sara, Van Hummelen Paul, Meistrich Marvin L, Lowe Xiu R, Hagemeister Fredrick B, Shelby Michael D, Bishop Jack B, Wyrobek Andrew J
Abstract excerpt
The objective of this research was to determine whether Novantrone, Oncovin, Velban, and Prednisone (NOVP) combination chemotherapy for Hodgkin's disease increases the frequencies of the specific types of aneuploid sperm that might elevate the risk of fathering a child with one of the major clinical aneuploidy syndromes, i.e., Down (disomy 21 sperm), Edward (disomy 18 sperm), Turner (nullisomy sex sperm), XYY...
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