Article
Genetic susceptibility to nasopharyngeal carcinoma within the HLA-A locus in Taiwanese.
International journal of cancer - 1 Mar 2003
Lu Cheng-Chan, Chen Jung-Chin, Jin Ying-Tai, Yang Hsiao-Bai, Chan Shih-Huang, Tsai Sen-Tien
Abstract excerpt
NPC is an epithelial tumor that is highly prevalent among the southern Chinese. Numerous studies have indicated that specific HLA haplotypes and genes within the HLA complex are associated with NPC. As a first effort to localize the gene responsible for susceptibility, the HLA-A, -B, and -A2 subtypes were examined for their association to NPC. Consistent with previous reports, frequencies of HLA-A2 [OR = 2.50, pc...
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