Article
The transcription factor Rim101p governs ion tolerance and cell differentiation by direct repression of the regulatory genes NRG1 and SMP1 in Saccharomyces cerevisiae.
Molecular and cellular biology - 1 Jan 2003
Lamb Teresa M, Mitchell Aaron P
Abstract excerpt
Environmental pH changes have broad consequences for growth and differentiation. The best-understood eukaryotic pH response pathway acts through the zinc-finger transcription factor PacC of Aspergillus nidulans, which activates alkaline pH-induced genes directly. We show here that Saccharomyces cerevisiae Rim101p, the pH response regulator homologous to PacC, functions as a repressor in vivo. Chromatin...
Topics
- Adenosine Triphosphatases
- Blotting, Northern
- Cation Transport Proteins
- Cell Differentiation
- Chromatin
- DNA-Binding Proteins
- Fungal Proteins
- Gene Deletion
- Gene Expression Regulation, Fungal
- Genotype
- Hydrogen-Ion Concentration
- Lac Operon
- Models, Biological